BIOENGINEERING STRATEGIES FOR THE PRIMARY RECOVERY OF BIOLOGICAL PRODUCTS
The increasing interest of the pharmaceutical companies to develop efficient and scale-up processes, that allow them to rapidly bring new products to the market, has forced them to develop new bioengineering strategies. One of the current trend is to exploit bioprocess integration and intensification approaches for the development of recovery and purification processes for biological products, particularly proteins. This article presents some cases of the results of the practical application of these approaches, using the techniques of aqueous two phase system and expanded bed adsorption. The experimental cases involve recovery of intracellular protein from baker´s yeast, in situ recovery of 6- pentyl-α-pyrone (coconut-like aroma compound) produced by Trichoderma harzianum, the development of a prototype process for the recovery of c-phycocyanin from Spirulina maxima and a new approach for the processing and recovery of inclusion bodies. It is expected that in the future the application of these strategies will facilitate the development of recovery systems for products of high commercial value and the optimization of already existing processes, attracting the attention of the industry for commercial applications.
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