DETECTION OF THE DEGRATION PRODUCTS AND PURITY OF DRUGS BY DSC

  • A. Brown-Gómez
  • T. Márquez
  • E. Besada
Keywords: drugs purity degree, differential scanning calorimetry (DSC), degradation products, reproducibility, reliability

Abstract

In this paperit is shown that the degradation products arising from the formulation and production of drugs can be monitored using thermoanalytical techniques, ensuring the drugs comply with the purity specifications required to deem them harmless for human consumption. The reproducibility of the results obtained with the DSC proved the reliability of the method for determining the drugs purity.

References

Black, P. B. y Pidgeon, D. (1990). Purity Determination of Standard Analytical Reference Materials by Differential Scanning Calorimetry. Government Reports Announcent Index (EUA), 90(23), 1-11.

Brown, A. y Michelena, G. (1993). Aplicación de la calorimetría diferencial de barrido al estudio del complejo coloidal hierrodextrana. Revista del Instituto Cubano de Investigaciones de los Derivados de la Caña de Azúcar 27, 45-59.

Connors, K. A., Amidon, G. L. y Stella, V. J. (1986). Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists. 2ª ed. Wiley, Nueva York, EUA.

De la Guardia, M., Salvador, A., Gómez, M. J. y De Benzo, Z. A. (1989). Rapid hydrolysis of benzodiazepines to benzophenones in a microwave oven. Analytica Chimica Acta 224(1), 123-126.

Dollimore, D. (1996).Thermal analysis. Analytical Chemistry 68(12), 63-71.

Domínguez, A. M., Brown, A., Montano, R. y Díaz, C. (1998). Evaluación de la pureza del dicloral urea como herbicida cañero. Revista del Instituto Cubano de Investigaciones de los Derivados de la Caña de Azúcar 32, 25-28.

Duswalt, A. A. (1974). Practice of obtaining kinetic data by differential scanning calorimetry. Thermochimica Acta 8(1-2), 57-68.

Gardner, C., Nakata, Y. y Walker, R. J. (1998). General pharmacology. General Pharmacology 31(5), I-IX.

Giron, D. (2000a). Characterization of pharmaceuticals by thermal analysis. American Pharmaceutical Review 3(2), 53-54, 56, 58-61.

Giron, D. (2000b). Characterization of pharmaceuticals by thermal analysis - Part II. American Pharmaceutical Review 3 (3), 43, 46-47, 50,52-53.

Haines, P.J. (1995). Thermal Methods of Analysis. Principles, Applications and Problems. Blackie Academic & Professional, Londres, Reino Unido.

Lachman, L. y De Luca, P. (1976). Kinetic principles and stability testing of pharmaceuticals. Theory and Practice in Industrial Pharmacy 2, 32-77.

Montgomery, D.C. (1991). Diseño y Análisis de Experimentos. Grupo Editorial Iberoamérica. México, D. F., México. NOM-073-SSA1 (1993). Norma Oficial Mexicana: Estabilidad de Medicamentos. Secretaría de Salud. México, D. F., México.
Published
2020-11-05
How to Cite
Brown-Gómez, A., Márquez, T., & Besada, E. (2020). DETECTION OF THE DEGRATION PRODUCTS AND PURITY OF DRUGS BY DSC. Revista Mexicana De Ingeniería Química, 3(3), 241-248. Retrieved from http://www.rmiq.org/ojs311/index.php/rmiq/article/view/2161

Most read articles by the same author(s)