Kinetics of the esterification reaction of glycol ethers with acetic acid to produce glycol ether acetates

Keywords: glycol ether acetate, esterification, kinetics, Amberlyst 15, pTSA


Glycol ether acetates are solvents of great industrial interest due to their low water solubility and slow evaporation rate. In the present work, the kinetics of esterification of glycol ethers with acetic acid to obtain glycol ether acetates was studied. Different synthesis conditions were evaluated, such as reaction temperature, catalyst type, catalyst loading and molar ratio between reactants. Uncatalyzed, catalyzed under homogeneous conditions with pTSA and under heterogeneous conditions with Amberlyst 15 were carried out. Second order kinetic model for the homogeneous system and Langmuir-Hinshelwood kinetic model for the heterogeneous system were proposed and the fit to the experimental data was performed to estimate the reaction rate constants. It was found that the maximum in reaction conversion depends mostly on the ratio between reactants, while temperature, catalyst type and catalyst loading have a significant effect on the reaction rate. Models’ predictions are in good agreement with the experimental data and the values of the reaction rate constants are consistent with values reported in other studies.


Che-Galicia, G., Martínez-Vera, C., Ruiz-Martínez, R., & Castillo-Araiza, C. (2020). Modelling of a fixed bed adsorber based on an isotherm model or an apparent kinetic model. Revista Mexicana De Ingeniería Química, 13(2), 539-553. Retrieved from

Correa-Leyva, C., Tejeda-Mansir, A., Martin-García, A., García, H., & Noriega-Rodríguez, J. (2019). Kinetics of the enzymatic esterification of n-3 polyunsaturated fatty acids to glycerol: multi-substrate multi-product ping-pong mechanism. Revista Mexicana De Ingeniería Química, 16(3), 805-812. Retrieved from

Deshmukh, K. S., V. C. Gyani and S. M. Mahajani (2009). Esterification of Butyl Cellosolve with Acetic Acid using Ion Exchange Resin in Fixed Bed Chromatographic Reactors. International Journal of Chemical Reactor Engineering 7(1), Article A2.

Eliana Paola, H.-B. and V.-H. Aida Luz (2018). Kinetics of nopyl acetate synthesis by homogeneously catalyzed esterification of acetic acid with nopol. Revista Facultad de Ingeniería Universidad de Antioquia 0(89), 16-25.

Gangadwala, J., A. Kienle, E. Stein and S. Mahajani (2004). Production of Butyl Acetate by Catalytic Distillation: Process Design Studies. Industrial & Engineering Chemistry Research 43(1), 136-143.

Gangadwala, J., S. Mankar, S. Mahajani, A. Kienle and E. Stein (2003). Esterification of Acetic Acid with Butanol in the Presence of Ion-Exchange Resins as Catalysts. Industrial & Engineering Chemistry Research 42(10), 2146-2155.

González-Brambila, M. M., Montoya de la Fuente, J. A., González-Brambila, O., & López-Isunza, F. (2020). A heterogeneous biodiesel production kinetic model. Revista Mexicana De Ingeniería Química, 13(1), 311-322. Retrieved from

González-Figueredo, C., Rojas-Rejón, O., Martínez-Vera-Negrete, A., Carranza-Volquarts, A., Estrada-Girón, F., & Peña-Partida, J. (2020). Kinetic parameters of Lactobacillus plantarum and Saccharomyces boulardii growing in a beet molasses culture media. Revista Mexicana De Ingeniería Química, 20(1), 467-478.

Hanika, J., J. Kolena and Q. Smejkal (1999). Butylacetate via reactive distillation — modelling and experiment. Chemical Engineering Science 54(21), 5205-5209.

Inayat, A., A. van Assche, J. H. Clark and T. J. Farmer (2018). Greening the esterification between isosorbide and acetic acid. Sustainable Chemistry and Pharmacy 7, 41-49.

Khire, S., P. Bhagwat, M. Fernandes, P. Gangundi and H. Vadalia (2012). Esterification of lower aliphatic alcohols with acetic acid in presence of different acid catalysts. Indian Journal of Chemical Technology 19(September), 342-350.

Lilja, J., D. Y. Murzin, T. Salmi, J. Aumo, P. Mäki-Arvela and M. Sundell (2002). Esterification of different acids over heterogeneous and homogeneous catalysts and correlation with the Taft equation. Journal of Molecular Catalysis A: Chemical 182-183, 555-563.

Liu, W., F. Wang, P. Meng and S.-Q. Zang (2020). Sulfonic Acids Supported on UiO-66 as Heterogeneous Catalysts for the Esterification of Fatty Acids for Biodiesel Production. Catalysts 10(11), 1271.

Liu, Y., E. Lotero and J. G. Goodwin (2006). A comparison of the esterification of acetic acid with methanol using heterogeneous versus homogeneous acid catalysis. Journal of Catalysis 242(2), 278-286.

Liu, Y., E. Lotero and J. G. Goodwin (2006). Effect of water on sulfuric acid catalyzed esterification. Journal of Molecular Catalysis A: Chemical 245(1), 132-140.

López-Badillo, M., Velasco-Hernández, M., García-Castro, M., Aranda-García, R., Galicia-Aguilar, J., Guevara-Espinosa, M., & Carreón-Rodríguez, V. (2019). Obtaining kinetic parameters of polyamide imide reaction. Revista Mexicana De Ingeniería Química, 19(2), 783-791.

Lux, S., T. Winkler, G. Berger and M. Siebenhofer (2015). Kinetic Study of the Heterogeneous Catalytic Esterification of Acetic Acid with Methanol Using Amberlyst15. Chem. Biochem. Eng. 29(4), 549-557.

Mekala, M. and V. R. Goli (2015). Kinetics of esterification of methanol and acetic acid with mineral homogeneous acid catalyst. Chinese Journal of Chemical Engineering 23(1), 100-105.

Mitran, G., T. Yuzhakova, I. Popescu and I.-C. Marcu (2015). Study of the esterification reaction of acetic acid with n-butanol over supported WO3 catalysts. Journal of Molecular Catalysis A: Chemical 396, 275-281.

Orjuela, A., A. J. Yanez, A. Santhanakrishnan, C. T. Lira and D. J. Miller (2012). Kinetics of mixed succinic acid/acetic acid esterification with Amberlyst 70 ion exchange resin as catalyst. Chemical Engineering Journal 188, 98-107.

Ren, Y. M., Z. C. Wu, R. C. Yang, T. X. Tao, J. J. Shao, Y. G. Gao, S. Zhang and L. Li (2013). A Simple Procedure for the Esterification and Transesterification Using p-Toluene Sulfonic Acid as Catalyst. Advanced Materials Research 781-784, 259-262.

Rönnback, R., T. Salmi, A. Vuori, H. Haario, J. Lehtonen, A. Sundqvist and E. Tirronen (1997). Development of a kinetic model for the esterification of acetic acid with methanol in the presence of a homogeneous acid catalyst. Chemical Engineering Science 52(19), 3369-3381.

Sert, E. and F. Atalay (2010). Determination of adsorption and kinetic parameters for butanol– Acetic acid esterification system catalysed by Amberlyst 15. Progress in Reaction Kinetics and Mechanism 35, 219-235.

Sharma, M., A. P. Toor and R. K. Wanchoo (2014). Reaction Kinetics of Catalytic Esterification of Nonanoic Acid with Ethanol over Amberlyst 15. International Journal of Chemical Reactor Engineering 12(1), 451-463.

Suman, T., S. Srinivas and S. M. Mahajani (2009). Entrainer Based Reactive Distillation for Esterification of Ethylene Glycol with Acetic Acid. Industrial & Engineering Chemistry Research 48(21), 9461-9470.

Vahteristo, K., A. Laari, H. Haario and A. Solonen (2008). Estimation of kinetic parameters in neopentyl glycol esterification with propionic acid. Chemical Engineering Science 63(3), 587-598.

Wang, S.-J. and H.-P. Huang (2011). Design of entrainer-enhanced reactive distillation for the synthesis of butyl cellosolve acetate. Chemical Engineering and Processing: Process Intensification 50(7), 709-717.

Yang, J., L. Zhou, X. Guo, L. Li, P. Zhang, R. Hong and T. Qiu (2015). Study on the esterification for ethylene glycol diacetate using supported ionic liquids as catalyst: Catalysts preparation, characterization, and reaction kinetics, process. Chemical Engineering Journal 280, 147-157.

Zhu, M.-H., Z.-J. Feng, X.-M. Hua, H.-l. Hu, S.-L. Xia, N. Hu, Z. Yang, I. Kumakiri, X. S. Chen and H. Kita (2016). Application of a mordenite membrane to the esterification of acetic acid and alcohol using sulfuric acid catalyst. Microporous and Mesoporous Materials 233, 171-176.

How to Cite
Camacho-Castillo, C., & Lugo-Uribe, L. (2022). Kinetics of the esterification reaction of glycol ethers with acetic acid to produce glycol ether acetates. Revista Mexicana De Ingeniería Química, 21(1), Cat2549.
Catalysis, kinetics and reactors